145 research outputs found
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Coexistence of Competing Species with a Directly Transmitted Pathogen
In this paper we consider models of two competing species that are both affected by a pathogen which is transmitted directly. We consider both mass action as well as frequency incidence models of disease spread, and Lotka-Volterra competition. Our aim is to address the interaction between competition and disease dynamics. We do this by presenting previously known results along with new results in a unified manner that stresses the role of the basic reproduction number as well as the relative strengths of intra- versus inter-specific competition for both species.
For both types of disease models we compute the basic reproduction numbers. For the mass action case we compute all the equilibria except infected coexistence, and analyze the equilibria for their stability. To analyze infected coexistence, we consider a simplified ecologically relevant model and prove a conjecture made in [18,9] about the stability of the infected coexistence equilibrium. The model with frequency incidence is shown to have a unique endemic equilibrium whose existence and stability depends on the value of the basic reproduction number
Dietary Supplements and Sports Performance: Introduction and Vitamins
Sports success is dependent primarily on genetic endowment in athletes with morphologic, psychologic, physiologic and metabolic traits specific to performance characteristics vital to their sport. Such genetically-endowed athletes must also receive optimal training to increase physical power, enhance mental strength, and provide a mechanical advantage. However, athletes often attempt to go beyond training and use substances and techniques, often referred to as ergogenics, in attempts to gain a competitive advantage. Pharmacological agents, such as anabolic steroids and amphetamines, have been used in the past, but such practices by athletes have led to the establishment of anti-doping legislation and effective testing protocols to help deter their use. Thus, many athletes have turned to various dietary strategies, including the use of various dietary supplements (sports supplements), which they presume to be effective, safe and legal
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Enemies and Turncoats: Bovine tuberculosis exposes pathogenic potential of Rift Valley fever virus in a common host, African Buffalo (Syncerus caffer)
The ubiquity and importance of parasite co-infections in populations of free-living animals is beginning to be recognized, but few studies have demonstrated differential fitness effects of single infection versus co-infection in free-living populations. We investigated interactions between the emerging bacterial disease bovine tuberculosis (BTB) and the previously existing viral disease Rift Valley fever (RVF) in a competent reservoir host, African buffalo, combining data from a natural outbreak of RVF in captive buffalo at a buffalo breeding facility in 2008 with data collected from a neighbouring free-living herd of African buffalo in Kruger National Park. RVF infection was twice as likely in individual BTB+ buffalo as in BTB− buffalo, which, according to a mathematical model, may increase RVF outbreak size at the population level. In addition, co-infection was associated with a far higher rate of fetal abortion than other infection states. Immune interactions between BTB and RVF may underlie both of these interactions, since animals with BTB had decreased innate immunity and increased pro-inflammatory immune responses. This study is one of the first to demonstrate how the consequences of emerging infections extend beyond direct effects on host health, potentially altering the dynamics and fitness effects of infectious diseases that had previously existed in the ecosystem on free-ranging wildlife populations.Keywords: Disease Ecology, Invasive Species, Parasite Interactions, Emerging Infectious Disease, Co-infection, Disease Dynamic
A hierarchical network approach for modeling Rift Valley fever epidemics with applications in North America
Rift Valley fever is a vector-borne zoonotic disease which causes high
morbidity and mortality in livestock. In the event Rift Valley fever virus is
introduced to the United States or other non-endemic areas, understanding the
potential patterns of spread and the areas at risk based on disease vectors and
hosts will be vital for developing mitigation strategies. Presented here is a
general network-based mathematical model of Rift Valley fever. Given a lack of
empirical data on disease vector species and their vector competence, this
discrete time epidemic model uses stochastic parameters following several PERT
distributions to model the dynamic interactions between hosts and likely North
American mosquito vectors in dispersed geographic areas. Spatial effects and
climate factors are also addressed in the model. The model is applied to a
large directed asymmetric network of 3,621 nodes based on actual farms to
examine a hypothetical introduction to some counties of Texas, an important
ranching area in the United States of America (U.S.A.). The nodes of the
networks represent livestock farms, livestock markets, and feedlots, and the
links represent cattle movements and mosquito diffusion between different
nodes. Cattle and mosquito (Aedes and Culex) populations are treated with
different contact networks to assess virus propagation. Rift Valley fever virus
spread is assessed under various initial infection conditions (infected
mosquito eggs, adults or cattle). A surprising trend is fewer initial
infectious organisms result in a longer delay before a larger and more
prolonged outbreak. The delay is likely caused by a lack of herd immunity while
the infections expands geographically before becoming an epidemic involving
many dispersed farms and animals almost simultaneously
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Spatiotemporal incidence of Zika and associated environmental drivers for the 2015-2016 epidemic in Colombia
Despite a long history of mosquito-borne virus epidemics in the Americas, the impact of the Zika virus (ZIKV) epidemic of 2015–2016 was unexpected. The need for scientifically informed decision-making is driving research to understand the emergence and spread of ZIKV. To support that research, we assembled a data set of key covariates for modeling ZIKV transmission dynamics in Colombia, where ZIKV transmission was widespread and the government made incidence data publically available. On a weekly basis between January 1, 2014 and October 1, 2016 at three administrative levels, we collated spatiotemporal Zika incidence data, nine environmental variables, and demographic data into a single downloadable database. These new datasets and those we identified, processed, and assembled at comparable spatial and temporal resolutions will save future researchers considerable time and effort in performing these data processing steps, enabling them to focus instead on extracting epidemiological insights from this important data set. Similar approaches could prove useful for filling data gaps to enable epidemiological analyses of future disease emergence events
A Nutrition and Conditioning Intervention for Natural Bodybuilding Contest Preparation: Case Study.
Bodybuilding competitions are becoming increasingly popular. Competitors are judged on their aesthetic
appearance and usually exhibit a high level of muscularity and symmetry and low levels of body fat. Commonly used techniques to improve physique during the preparation phase before competitions include dehydration, periods of prolonged fasting, severe caloric restriction, excessive cardiovascular exercise and inappropriate use of diuretics and anabolic steroids. In contrast, this case study documents a structured nutrition and conditioning
intervention followed by a 21 year-old amateur bodybuilding competitor to improve body composition, resting and
exercise fat oxidation, and muscular strength that does not involve use of any of the above mentioned methods.
Over a 14-week period, the Athlete was provided with a scientifically designed nutrition and conditioning plan that
encouraged him to (i) consume a variety of foods; (ii) not neglect any macronutrient groups; (iii) exercise regularly
but not excessively and; (iv) incorporate rest days into his conditioning regime. This strategy resulted in a body
mass loss of 11.7 kg’s, corresponding to a 6.7 kg reduction in fat mass and a 5.0 kg reduction in fat-free mass.
Resting metabolic rate decreased from 1993 kcal/d to 1814 kcal/d, whereas resting fat oxidation increased from
0.04 g/min to 0.06 g/min. His capacity to oxidize fat during exercise increased more than two-fold from 0.24 g/min
to 0.59 g/min, while there was a near 3-fold increase in the corresponding exercise intensity that elicited the
maximal rate of fat oxidation; 21% V̇
O2max to 60% V̇ O2max. Hamstring concentric peak torque decreased (1.7 to 1.5 Nm/kg), whereas hamstring eccentric (2.0 Nm/kg to 2.9 Nm/kg), quadriceps concentric (3.4 Nm/kg to 3.7 Nm/kg) and quadriceps eccentric (4.9 Nm/kg to 5.7 Nm/kg) peak torque all increased. Psychological mood-state (BRUMS scale) was not negatively influenced by the intervention and all values relating to the Athlete’s mood-state remained below average over the course of study. This intervention shows that a structured and scientifically supported nutrition strategy can be implemented to improve parameters relevant to bodybuilding competition and importantly the health of competitors, therefore questioning the conventional practices of bodybuilding preparation
Elite squash players nutrition knowledge and influencing factors
Background
There is a reported mismatch between macronutrient consumption and contemporary macronutrient guidelines in elite standard squash players. Suboptimal dietary practices could be due to a lack of nutrition knowledge among players. Subsequently, the purpose of this study was to assess the sports nutrition knowledge of elite squash players through the Nutrition for Sport Knowledge Questionnaire (NSKQ) and provide an indication of whether players require nutrition support to increase their nutrition knowledge.
Methods
This cross-sectional study assessed the nutrition knowledge of 77 elite squash players via the NSKQ over the period of June 2020 to August 2020.
Results
Players conveyed average nutrition knowledge with a mean NSKQ score of 48.78 ± 10.06 (56.07% ± 11.56%). There were no significant differences in NSKQ score between male and female players (p = .532). There was found to be a weak positive association between world ranking and NSKQ score (r = .208) and age and NSKQ score (r = .281). Players who had a relevant undergraduate degree (e.g. BSc Sport & Exercise Science) had significantly greater NSKQ score than players with no relevant qualifications (p = .022). Players who consulted a sports nutritionist to obtain their main source of nutrition information were shown to have significantly greater knowledge than those who acquired knowledge from a sports scientist (p = .01) or the internet / social media (p = .007).
Conclusions
Players should consult with a sports nutritionist to increase their sport nutrition knowledge. Future research should quantify the effectiveness of a nutritional education intervention at increasing nutrition knowledge in players
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